The severe phenotype emerged as a latent condition with signs of a dysbalanced immune response. LCA revealed a set of benign, symptomatic, and severe atopy phenotypes. AГ‚В path analysis among sensitized children revealed that among all features of severe atopy, only excessive sIgE production early in life affected asthma risk. Severe atopy was associated with an increased IL-5/IFN-ГЋВі ratio. LCA detected consistently in both cohorts a distinct group of children with severe atopy characterized by high seasonal sIgE levels and a strong propensity for asthma hay fever eczema and impaired lung function, also in children without an established asthma diagnosis. Latent classes were related to atopic disease manifestations with higher sensitivity and specificity than the classical definitions. The LCA classified predominantly by type and multiplicity of sensitization (food vs inhalant), allergen combinations, and sIgE levels. Cytokine levels were measured in the PASTURE cohort. Phenotypes were defined by means of LCA in 680 children of the Multizentrische Allergiestudie (MAS) and 766 children of the Protection against allergy: Study in Rural Environments (PASTURE) birth cohorts and compared with classical nondisjunctive definitions of seasonal, perennial, and food sensitization with respect to atopic diseases and lung function. We sought to define phenotypes of atopic sensitization over the first 6Г‚В years of life using a latent class analysis (LCA) integrating 3 dimensions of atopy: allergen specificity, time course, and levels of specific IgE (sIgE). For atopy, definition of phenotypes during childhood is less clear. Phenotypes of childhood-onset asthma are characterized by distinct trajectories and functional features. Hose, Alexander J Depner, Martin Illi, Sabina Lau, Susanne Keil, Thomas Wahn, Ulrich Fuchs, Oliver Pfefferle, Petra Ina SchmauГѓЕёer-Hechfellner, Elisabeth Genuneit, Jon Lauener, Roger Karvonen, Anne M Roduit, Caroline Dalphin, Jean-Charles Riedler, Josef Pekkanen, Juha von Mutius, Erika Ege, Markus J

Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts.

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